王涛，男，1976年4月生，空军军医大学（原第四军医大学）基础医学院遗传学与发育生物学教研室副主任，副教授，硕士研究生导师。首批总后优秀青年科技人才扶持对象、首届中国免疫学会青年学者奖获得者，肿瘤生物学国家重点实验室青年学术骨干，长期从事免疫学和肿瘤生物学研究，在肿瘤靶向杀伤、免疫细胞分化、肿瘤和免疫细胞表观遗传调控等研究方向上取得了突出成绩，获得了一批创新性成果。现任陕西省遗传学会理事，Int J Cancer、Oncotarget、Cancer Biother Radio、Acta Bioch Bioph Sin等SCI期刊审稿专家，细胞与分子免疫学杂志特约编辑。近年来先后在Cancer Research、Blood、Biomaterial、Int J Cancer等国际权威杂志发表SCI论文30余篇，先后承担国家自然科学基金面上项目3项，国家自然科学基金青年基金1项，作为课题副组长承担国家重大新药创制专项和“973”课题各1项，参与国家重大传染病防治专项、“863”课题、国家自然科学基金重点项目等多个国家级科研课题。曾获陕西省科技进步一等奖1项，获国家发明专利1项。
1.Huo Y, Li BY, Lin ZF, Wang W, Jiang XX, Chen X, Xi WJ, Li YF, Yang AG, Chen SY, Wang T*. MYSM1 is essential for maintaining HSC quiescence and survival. Med Sci Monit. 2018 Mar. [Epub ahead of print]
2.Xi WJ, Chen X, Sun JB, Zuo BL, Wang W, Huo Y, Zheng GX, Wu JH, Li YF, Lin ZF, Wen WH, Yang AG, Wang T*. Combined valproic acid and 5-aza-2’-deoxycytidine synergistically inhibits human clear cell renal cell carcinoma growth and migration. Med Sci Monit. 2018 Jan. [Epub ahead of print]
3.Wang W, Xiao X, Chen X, Huo Y, Xi WJ, Lin ZF, Zhang D, Li YF, Yang F, Wen WH, Yang AG, Wang T*. Tumor-suppressive miR-145 co-repressed by TCF4-β-catenin and PRC2 complexes forms double-negative regulation loops with its negative regulators in colorectal cancer. Int J Cancer. 2018 Jan 15;142(2):308-321.
4.Wang W, Ji G, Xiao X, Chen X, Qin WW, Yang F, Li YF, Fan LN, Xi WJ, Huo Y, Wen WH, Yang AG*, Wang T*. Epigenetically regulated miR-145 suppresses colon cancer invasion and metastasis by targeting LASP1, Oncotarget. 2016 Oct 18;7(42):68674-68687
5.Qin WW, Zhang R, Chen RA, Li GH, Ji YR, Liu L*, Wang T*. MicroRNA-145 induces cell cycle arrest in G1 phase by directly targeting KLF5 in colon cancer. Int J Clin Exp Pathol 2016;9(5):5197-5209.
6.Yang F, Wang W, Zhou C, Xi W, Yuan L, Chen X, Li Y, Yang A, Zhang J, Wang T*. MiR-221/222 promote human glioma cell invasion and angiogenesis by targeting TIMP2, Tumour Biol. 2015 May;36(5):3763-73.
7.Wang T, Nandakumar V, Jiang XX, Jones L, Yang AG, Huang XF, Chen SY*. The control of hematopoietic stem cell maintenance, self-renewal and differentiation by Mysm1-mediated epigenetic regulation, Blood. 2013 Oct 17;122(16):2812-22.
8.Bai JX, Yan B, Zhao ZN, Xiao X, Qin WW, Zhang R, Jia LT, Meng YL, Jin BQ, Fan DM, Wang T*, Yang AG*. Tamoxifen represses miR-200 microRNAs and promotes epithelial-to-mesenchymal transition by up-regulating c-Myc in endometrial carcinoma cell lines, Endocrinology. 2013 Feb;154(2):635-45
9.Zhao ZN, Bai JX, Zhou Q, Yan B, Qin WW, Jia LT, Meng YL, Jin BQ, Yao LB, Wang T*, Yang AG*. TSA Suppresses miR-106b-93-25 Cluster Expression through Downregulation of MYC and Inhibits Proliferation and Induces Apoptosis in Human EMC, PLoS One. 2012;7(9):e45133.
10.Ren JL, Meng YL, Hu B, Jia LT, Zhang R, Xu YM, Xie QS, Zhang YQ, Jin BQ, Chen SY, Wang T*, Yang AG*. The effect of direct translocation across endosomes on the cytotoxicity of the recombinant protein e23sFv-Fdt-casp6 to HER2 positive gastric cancer cells, Biomaterials. 2011 Oct;32(30):7641-50.
11.Xue Q, Guo ZY, Li W, Wen WH, Meng YL, Jia LT, Wang J, Yao LB, Jin BQ, Wang T*, Yang AG*. Human activated CD4(+) T lymphocytes increase IL-2 expression by downregulating microRNA-181c, Mol Immunol. 2011 Jan;48(4):592-9.
12.Wang T, Zhao J, Ren JL, Zhang L, Wen WH, Zhang R, Qin WW, Jia LT, Yao LB, Zhang YQ, Chen SY, Yang AG*. Recombinant immunoproapoptotic proteins with furin site can translocate and kill HER2-positive cancer cells, Cancer Res. 2007 Dec 15;67(24):11830-9.
13.Jiang XX, Nguyen Q, Chou Y, Wang T, Nandakumar V, Yates P, Jones L, Wang L, Won H, Lee HR, Jung JU, Müschen M, Huang XF, Chen SY*. Control of B cell development by the histone H2A deubiquitinase MYSM1, Immunity. 2011 Dec 23;35(6):883-96.
14.Bao W, Fu HJ, Xie QS, Wang L, Zhang R, Guo ZY, Zhao J, Meng YL, Ren XL, Wang T, Li Q, Jin BQ, Yao LB, Wang RA, Fan DM, Chen SY, Jia LT, Yang AG*. HER2 interacts with CD44 to up-regulate CXCR4 via epigenetic silencing of microRNA-139 in gastric cancer cells. Gastroenterology. 2011 Dec;141(6):2076-2087.
15.Wang L, Zhang X, Jia LT, Hu SJ, Zhao J, Yang JD, Wen WH, Wang Z, Wang T, Zhao J, Wang RA, Meng YL, Nie YZ, Dou KF, Chen SY, Yao LB, Fan DM, Zhang R, Yang AG*. c-Myc-mediated epigenetic silencing of microRNA-101 contributes to dysregulation of multiple pathways in hepatocellular carcinoma. Hepatology. 2014 May;59(5):1850-63.
16.Wen WH, Liu JY, Qin WJ, Zhao J, Wang T, Jia LT, Meng YL, Gao H, Xue CF, Jin BQ, Yao LB, Chen SY, Yang AG*. Targeted inhibition of HBV gene expression by single-chain antibody mediated small interfering RNA delivery. Hepatology. 2007 Jul;46(1):84-94.
