药理学教研室-吴玉梅

吴玉梅，女，博士，空军军医大学药学系药理学教研室副教授，硕士研究生导师。中国神经科学学会、中国药理学会分会青年委员、陕西省药理学会理事、国家自然科学基金委评审专家，第四军医大学“优秀硕士研究生指导教师”、“十佳教学能手”、“双十佳精品课教员”、“精品课教员”、教学先进个人；2009年荣获美国神经免疫药理学“青年学者一等奖”，2016年荣获陕西省科学技术一等奖，2018年荣获全国药理学青年教师教学比赛二等奖。1998年获第四军医大学临床医学专业医学学士学位；1999-2002年师从中国科学院院士鞠躬教授，获神经生物学硕士学位；2003-2006年师从药理学三级教授罗晓星，获药理学博士学位；2007-2009年留学美国University of Nebraska Medical Center从事博士后研究工作，导师郑加麟教授（现任同济大学医学院院长）。热衷科研，具有完整的科研思维体系，能够紧跟本研究领域的热点和焦点问题并开展研究，研究工作取得了不俗的成绩。负责国家自然科学基金课题3项、陕西省国际合作重点项目1项、军事医学提升计划课题1项，军队重大项目课题子课题1项等共9项科研项目研究。发表论文30余篇，主编教材1部，参编专著10部。研究方向：（1）精神障碍性疾病发病机制；（2）神经系统相关疾病预防、治疗新靶点的发掘与新药研发；（3）中药单体神经保护机制。

代表性论著：

1. Yu W#, Wang L#, Yang L#, Li YJ, Wang M, Qiu C, Yang Q, Li XB, Huang YL, Liu R*, Wu YM*(CA). Activation of LXRβ signaling in amygdala confers anxiolytic effects through rebalancing excitatory and inhibitory neurotransmission upon acute stress. Neurotherapeutics 2020 Apr 15.doi: 10.1007/s13311-020-00857-y (IF=5.55, online ahead of print)

2. Li YJ#, Zhang K#, Sun T#, Wang J, Guo YY, Yang L, Yang Q, Li YJ, Liu SB, Zhao MG*, Wu YM*(CA). Epigenetic suppression of liver X receptor  in anterior cingulate cortex by HDAC5 drives CFA-induced chronic inflammatory pain. J Neuroinflammation 2019; 16(1): 132. (IF=5.7)

3. Li YJ#, Li YJ#, Zhang K, Yang LD, Zheng KY, Wei XM, Yang Q, Niu WM, Zhao MG, Wu YM*(CA). Silibinin exerts antidepressant effects by improving neurogenesis through BDNF/TrkB pathway. Behav Brain Res 2018; 348:184-191. (IF=3.0)

4. Sun T#, Li YJ#, Tian QQ, Wu Q, Feng D, Xue Z, Guo YY, Yang L, Zhang K, Zhao MG, Wu YM*(CA). Activation of Liver X receptor -enhancing neurogenesis ameliorates cognitive impairment induced by chronic cerebral hypoperfusion. Exp Neurol 2018; 304:21-29. (IF=4.71)

5. Wang XK#, Sun T#, Li YJ#, Wang YH#, Li YJ, Yang LD, Feng D, Zhao G, Wu YM*(CA). A novel thiazolidinediones ATZD2 rescues memory deficits in a rat model of Type 2 Diabetes through antioxidant and inflammation. Oncotarget 2017; 8(64):107409-107422. (IF=5.17)

6. Wan Q#, Ma X#, Zhang ZJ, Sun T, Xia F, Zhao G, Wu YM*(CA). Ginsenoside Reduces Cognitive Impairment during Chronic Cerebral Hypoperfusion through Brain-Derived Neurotrophic Factor Regulated by Epigenetic Modulation. Mol Neurobiol 2017; 54(4):2889-2900. (IF=6.19)

7. Sun T#, Wang J#, Li X#, Li YJ, Feng D, Shi WL, Zhao MG, Wang JB*, Wu YM*(CA). Gastrodin relieved complete Freund's adjuvant-induced spontaneous pain by inhibiting inflammatory response. Int Immunopharmacol 2016; 41:66-73. (IF=2.55)

8. Yang L#, Wang M#, Guo YY#, Sun T, Li YJ, Yang Q, Zhang K, Liu SB, Zhao MG*, Wu YM*(CA). Systemic inflammation induces anxiety disorder through CXCL12/CXCR4 pathway. Brain Behav Immun 2016; 56:352-62. (IF=5.90)

9. Wang M#, Li YJ#, Ding Y, Zhang HN, Sun T, Zhang K, Yang L, Guo YY, Liu SB, Zhao MG*, Wu YM*(CA). Silibinin prevents autophagic cell death upon oxidative stress in cortical neurons and cerebral ischemia-reperfusion injury. Mol Neurobiol 2016; 53(2): 932-43. (IF=6.19)

10. Wu YM#, Jin R#, Yang L#, Zhang J, Yang Q, Guo YY, Li XB, Liu SB, Luo XX*, Zhao MG*(CA). Phosphatidylinositol-3-kinase/protein kinase B is responsible for the protection of Paeoniflorin upon H2O2-induced neural progenitor cell injury. Neuroscience 2013; 240:54-62. (IF=3.38)

11. Ma L#, Wu YM#, Guo YY#, Yang Q, Feng B, Song Q, Liu SB, Zhao DQ, Zhao MG*(CA). Nicotine addiction reduces the large-conductance Ca2+-activated potassium channels expression in the nucleus accumbens. Neuromolecular Med 2013; 15(2): 227-37.(Co-first author, IF=5.0)

12. Yin W#, Ma L#, Zhang J, Huang K, Yang Q, Guo YY, Liu SB, Liu YH*, Wu YM*(CA). The Migration of neural progenitor cell mediated by SDF-1 is NF-kappaB/HIF-1alpha dependent upon hypoxia. CNS Neuroscience & Therapeutics 2013; 19(3): 145-53. (IF=4.44)

13. Li YJ#, Yang Q#, Zhang K#, Guo YY, Li XB, Yang L, Zhao MG*, Wu YM*(CA). Cytisine confers neuronal protection against excitotoxic injury by down-regulating GluN2B-containing NMDA receptors. Neurotoxicology 2013; 34: 219-25. (IF=3.09)

14. Yang L#, Li XB#, Yang Q#, Zhang K, Zhang N, Guo YY, Feng B, Zhao MG*, Wu YM*(CA). The Neuroprotective Effect of Praeruptorin C Against NMDA-induced Apoptosis Through Down-regulating of GluN2B-containing NMDA Receptors. Toxicol in vitro 2013; 27: 908-14. (IF=2.78)

15. Zhang K#, Yang Q#, Yang L#, Li YJ#, Wang XS, Li YJ, Dang RL, Guan SY, Guo YY, Sun T, Wu YM, Liu A, Zhang Y, Liu SB*, Zhao MG*(CA). CB1 agonism prolongs therapeutic window for hormone replacement in ovariectomized mice. J Clin Invest 2019; 130: 2333-2350. (IF=12.28)

16. Li XB#, Liu A#, Yang L, Zhang K, Wu YM, Zhao MG*, Liu SB*(CA). Antidepressant-like effects of translocator protein (18 kDa) ligand ZBD-2 in mouse models of postpartum depression. Mol Brain 2018; 11(1): 12. (IF=3.41)

17. Zhang K#, Li YJ#, Feng D#, Zhang P, Wang YT, Li X, Liu SB, Wu YM, Zhao MG*(CA). Imbalance between TNFα and progranulin contributes to memory impairment and anxiety in sleep-deprived mice. Sci Rep 2017; 7: 43594. (IF=4.26)

18. Yang Q, Yang L, Zhang K, Guo YY, Liu SB, Wu YM, Li XQ, Song Q, Zhuo M, Zhao MG. Increased coupling of caveolin-1 and estrogen receptor α contributes to the fragile X syndrome. Ann Neurol. 2015; 77(4):618-36. (IF=10.09)

19. Li XB, Guo HL, Shi TY, Yang L, Wang M, Zhang K, Guo YY, Wu YM, Liu SB, Zhao MG. Neuroprotective effects of a novel translocator protein (18 kDa) ligand, ZBD‐2, against focal cerebral ischemia and NMDA-induced neurotoxicity. Clin Exp Pharmacol Physiol 2015; 42(10):1068-74.

20. Yang L#, Yang Q#, Zhang K, Li YJ, Wu YM, Liu SB, Zheng LH, Zhao MG*(CA). Neuroprotective effects of daphnetin against NMDA receptor-mediated excitotoxicity. Molecules 2014; 19(9): 14542-55. (IF=2.41)