化学制药学教研室-王海波

王海波，1976年3月生。空军军医大学药学系化学制药学教研室副教授，硕士研究生导师，总后教学标兵。2002年硕士毕业于西北大学化学系，2008年获得第四军医大学药理学专业博士学位。主要从事生物功能分子的设计、合成及药效学活性筛选等研究工作。主持国家自然科学基金面上项目和青年项目各1项，陕西省重点研发项目、陕西省自然科学基金各1项、校军事医学提升计划项目1项。2016年获得军队三类人才津贴，2015年获得陕西省科技进步一等奖（排名第5）。获得授权发明专利2项，发表科研论文20余篇。

代表性论文

1. Linlin Jing, Shao Jin, Sun Wei, Lan Ting, Zhengping Jia, Huiping Ma, Haibo Wang*. Protective effects of two novel nitronyl nitroxide radicals on heart failure induced by hypobaric hypoxia. Life Sciences, 2019, doi.org/10.1016/j.lfs.2019.05.037.

2. Min Tian, Ting Lan, Min Gao, Bo Li, Gai Zhang,, Hai-Bo Wang*. Synthesis and Characterization of Two Chiral Pyrrolyl a-Nitronyl Nitroxide Radicals and Determination of their Cytotoxicity and Radioprotective Properties in C6 Cells and Mice under Ionizing Radiation. Aust. J. Chem., 2019, 72(7): 492-500, doi.org/10.1071/CH18625.

3. Fen Wang, Peng Gao, Pin Meng, Yongbin Chen, Yanyun Lin, Guozhen Guo, Guirong Ding*, Haibo Wang*. Radio-protective effect and Mechanism of 4-Acetamido-2,2,6,6- tetramethylpiperidin-1-oxyl in HUVEC cells. Environmental Health and Preventive Medicine, 2017, 22: 14.

4. LinLin Jing, HuiPing Ma, XiaoLi Sun and HaiBo Wang*. Crystal structure of (S)-2-(2,2′-diethoxy-[1,1′-binaphthalen] -6-yl)-4,4,5,5-tetra-methyl-2-imidazoline-1-oxyle, C31H33N2O3, Z. Kristallogr. NCS, 2015, 230(4): 375-377.

5. Haibo Wang, Lei Chen, Xiuling Tang, Yanyan Jia , Guangqing Li , Xiaoli Sun*, Aidong Wen*. Synthesis and characterization of novel polar-embedded silica stationary phases for use in reversed-phase high-performance liquid chromatography. Journal of Chromatography A, 2013, 1271, 153-162.

6. Haibo Wang, Yujing Jia, Peng Gao, Ying Cheng, Ming Cheng, Chentao Lu, Siyuan Zhou*, Xiaoli Sun*. Synthesis, radioprotective activity and pharmacokinetics characteristic of a new stable nitronyl nitroxyl radical-NIT2011. Biochimie, 2013, 95, 1574-1581.

7. Haibo Wang, Linlin Jing, Zhuo Xiang, Pingan Wang, Xiaoli Sun, Ru Jiang*. Synthesis and fluorescence-tuning of novel nitroxides with a binaphthyl framework. Bulletin of the Chemical Society of Japan, 2011, 84, 341-343.

8. Guangguo Tan, Haibo Wang (co-first author), Jianlin Yuan, Weijun Qin, Xin Dong, Hong Wu, Ping Meng. Three serum metabolite signatures for diagnosing low-grade and highgrade bladder cancer. Scientific Reports, 2017, 7: 46176, doi: 10.1038/srep46176.

9. WenJuan Han, Lei Chen, HaiBo Wang (co-first author), XiangZeng Liu, SanJue Hu, XiaoLi Sun*, and Ceng Luo*. A Novel Nitronyl Nitroxide with Salicylic AcidFramework Attenuates Pain Hypersensitivity and EctopicNeuronal Discharges in Radicular Low Back Pain, Neural Plasticity., 2015, 1-14.

10. Tianyao Shi, Daqing Zhao, Haibo Wang (co-first author), Shufang Feng, Shuibing Liu, Xianghao Xing,Yang Qu, Peng Gao, Xiaoli Sun, Minggao Zhao*. A New Chiral Pyrrolyl α-Nitronyl Nitroxide Radical Attenuates β-Amyloid Deposition and Rescues Memory Deficits in a Mouse Model of Alzheimer Disease. Neurotherapeutics, 2013, 10, 340-353.